Table 1.
Characteristics of patients with T1D and macroalbuminuria according to subcohort defined by date of enrollment
| Characteristic | Subcohort |
P | ||
|---|---|---|---|---|
| 1991 to 1995 (n = 113) | 1996 to 2000 (n = 112) | 2001 to 2004 (n = 198) | ||
| Men (%) | 53.1 | 53.6 | 53.5 | 1.0 |
| Age (years) | 34.1 ± 5.7 | 37.6 ± 7.2 | 41.8 ± 9.7 | <0.0001 |
| Age at T1D diagnosis (years) | 11.5 ± 6.7 | 11.6 ± 7.2 | 15.3 ± 8.9 | <0.0001 |
| T1D duration (years) | 22.6 ± 6.7 | 26.0 ± 8.2 | 26.5 ± 8.9 | 0.0001 |
| Duration of care at Joslin (years) | 17.4 ± 8.8 | 21.2 ± 10.7 | 18.0 ± 12.0 | 0.05 |
| HbA1c (%) | 9.1 ± 1.6 | 9.4 ± 1.9 | 8.7 ± 1.6 | 0.01 |
| Body mass index (kg/m2) | 25.1 ± 4.3 | 25.3 ± 4.8 | 27.6 ± 6.4 | <0.0001 |
| Patients using lipid-lowering drugs (%) | 8.0 | 10.7 | 42.4 | <0.0001 |
| Total cholesterol (mg/dl) | 228 ± 64 | 212 ± 51 | 202 ± 49 | <0.0001 |
| Current smokers (%) | 28.1 | 26.4 | 20.7 | 0.30 |
| Systolic blood pressure (mmHg) | 137 ± 20 | 134 ± 18 | 131 ± 17 | 0.006 |
| Diastolic blood pressure (mmHg) | 81 ± 10 | 80 ± 9 | 76 ± 10 | <0.0001 |
| Patients using ACE-I or ARB (%) | 55.8 | 62.5 | 81.8 | <0.0001 |
| ACR (mg/g) | 967 (526 to 1667) | 736 (442 to 1310) | 778 (465 to 1795) | 0.15 |
| eGFR (ml/min) | 70 ± 35 | 73 ± 37 | 60 ± 30 | 0.005 |
The data are the means ± SD or percent. eGFR, MDRD estimate of glomerular filtration rate based on serum creatinine.