Figure 2.

Regional Association Plot for the CUBN gene region. CKDGen Consortium stage 1 analyses (A), CARe IBC SNP chip results in participants of European Ancestry (B) and African ancestry (C). log₁₀ P values are plotted versus genomic position (build 36). The lead SNP in each region is labeled. Other SNPs in each region are color-coded based on their LD to the lead SNP (LD based on the HapMap CEU and YRI for the participants of African ancestry; see color legend). Gene annotations are based on UCSC Genome Browser (RefSeq Genes, b36) and arrows indicate direction of transcription. Graphs were generated using the software SNAP (http://www.broadinstitute.org/mpg/snap/index.php). Regions vary between panels because there was no coverage beyond the CUBN gene on the IBC chip used to generate panels B and C.