Table 1.
Study sample characteristics in the CKDGen and CARe Consortia
| Study | na | Women % | Age, years | UACRb | MA % | CKD % | HTN % | DM % |
|---|---|---|---|---|---|---|---|---|
| Stage 1: GWAS | ||||||||
| Amish | 744 | 45.0 | 42.8 | 3.8 (2.2, 6.1) | NA | 1.2 | 11.6 | 0.7 |
| ARIC | 6525 | 53.1 | 63.1 | 3.9 (2.0, 7.7) | 9.4 | 9.1 | 42.9 | 13.6 |
| BLSA | 354 | 46.9 | 69.8 | 7 (4.4, 11.0) | NA | 15.5 | 53.7 | 14.4 |
| CHS | 1865 | 60.8 | 71.2 | 9.3 (5.3, 19.9) | 23.0 | 16.0 | 61.2 | 13.7 |
| Colaus | 5311 | 53.2 | 53.4 | 5.1 (3.4, 9.1) | 9.5 | 3.8 | 36.1 | 9.6 |
| EPIC | 2371 | 53.3 | 59.2 | 3.6 (1.5, 8.3) | 8.1 | NA | 49.3 | 3.0 |
| Fenland | 1398 | 56.2 | 44.9 | 4.5 (3.2, 7.1) | 5.5 | 0.9 | 18.9 | 1.4 |
| Framingham Heart Study | 6523 | 53.2 | 47.6 | 4.6 (2.6, 9.9) | 9.6 | 3.4 | 27.4 | 5.3 |
| KORA F3 | 1530 | 50.5 | 62.5 | 4.9 (2.1, 11.1) | 11.7 | 10.8 | 41.1 | 10.3 |
| KORA F4 | 1803 | 51.3 | 60.9 | 10.7 (7.0, 18.4) | 20.9 | 7.0 | 20.9 | 9.2 |
| Micros | 503 | 56.3 | 46.0 | NA | 5.4 | 3.6 | 40.6 | 3.7 |
| SHIP | 2653 | 48.9 | 55.3 | 8.9 (5.0, 20.6) | 25.3 | 8.5 | 54.2 | 12.4 |
| Stage 2 | ||||||||
| AGES | 3196 | 57.9 | 76.4 | 2.66 (1.2, 7.0) | 11.9 | 24.2 | 80.6 | 11.6 |
| Amish | 695 | 54.4 | 47.2 | 7 (4.3, 13.5) | NA | NA | 21.0 | 11.5 |
| ARIC | 759 | 56.0 | 63.0 | 3.9 (2.1, 7.5) | 7.6 | 7.7 | 39.3 | 13.1 |
| GENOA | 987 | 43.0 | 59.0 | 3.1 (1.7, 5.9) | 6.4 | 10.7 | 73.5 | 15.8 |
| Health ABC | 211 | 27.0 | 73.9 | 13.9 (6.1, 49.6) | 42.2 | 25.0 | 64.1 | 100.0 |
| HUNT | 2386 | 54.5 | 51.4 | 6.1 (4.4, 9.2) | 8.6 | 4.7 | 43.4 | 4.0 |
| KORA F3 | 1392 | 52.4 | 50.8 | 4.4 (1.9, 9.6) | 10.9 | 5.5 | 28.6 | 4.5 |
| KORA F4 | 1197 | 52.3 | 49.2 | 10.1 (6.6, 20.1) | 23.7 | 5.9 | 13.4 | 4.0 |
| KORCULA | 863 | 63.9 | 56.3 | 4.6 (2.5, 10.4) | 12.4 | 7.5 | 57.3 | 10.4 |
| Nurses Health Study | 4138 | 100.0 | 58.2 | 2.8 (1.7, 4.5) | 3.6 | 10.4 | 36.1 | 4.4 |
| PREVEND | 7803 | 50.5 | 49.5 | 7.1 (4.8, 13.3) | 16.7 | 6.4 | 33.5 | 3.7 |
| SAPHIR Study | 1707 | 37.3 | 51.4 | 3.8 (2.3, 8.2) | 9.8 | 1.4 | 56.5 | 3.2 |
| SORBS | 877 | 58.7 | 48.0 | 6.8 (4.6, 13.5) | 13.6 | 4.0 | 52.1 | 9.2 |
| SPLIT | 472 | 56.5 | 49.3 | 2.5 (1.3, 5.8) | 7.8 | 3.6 | 39.4 | 5.1 |
| ULSAM | 1063 | 0.0 | 71.0 | 7.5 (4.9, 16.1) | 15.9 | 15.2 | 74.0 | 11.0 |
| CARe Consortium | ||||||||
| European Americansc | ||||||||
| CARDIA | 1242 | 50.4 | 40.7 | 4.4 (3.3, 6.9) | 4.5 | 0.53 | 9.3 | 5.0 |
| MESA | 2289 | 52.1 | 62.7 | 4.7 (3.1, 8.6) | 9.6 | 9.7 | 38.7 | 6.3 |
| African Americans | ||||||||
| ARIC | 2256 | 64.5 | 61.7 | 2.7 (0.9, 9.6) | 16.3 | 7.3 | 70.9 | 27.7 |
| CARDIA | 1089 | 56.3 | 39.5 | 4.3 (3.1, 7.4) | 9.6 | 0.9 | 24.7 | 6.4 |
| CHS | 426 | 64.3 | 72.1 | 10.9 (5.0, 26.9) | 31.9 | 18.4 | 68.2 | 24.4 |
| Jackson Heart Study | 1530 | 58.5 | 51.8 | 6 (4.0, 13.0) | 17.8 | 5.9 | 58.8 | 16.1 |
| MESA | 1680 | 54.6 | 62.2 | 5.5 (3.1, 13.2) | 16.6 | 8.5 | 59.8 | 17.8 |
Data presented as means except where otherwise indicated. DM, diabetes; HTN, hypertension.
aRefers to the successfully genotyped and analyzed sample with UACR or MA data, which may differ from the recruited sample described in Supplemental online Methods.
bMedian (interquartile range: 25th percentile, 75th percentile).
cRefers to studies that are nonoverlapping with CKDGen; the sample size of ARIC, CHS, and FHS in CARe was 7687, 2073, and 6208, respectively.