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ADAM-mediated cleavage in the juxtamembrane domain. A, illustration of WT corin and the Fz1 deletion mutant (ΔFz1). HEK 293 cells expressing WT corin and the ΔFz1 mutant incubated without (B) or with GM6001 (C) or benzamidine (Benz) (D). Soluble corin fragments in the medium were analyzed by Western blotting. Lysate was included as a control. Data are from representative experiments that were repeated at least three times.
