FIGURE 6.
11β-HSD2 (negative feedback enzyme) is induced by glucocorticoids. A, expression of 11β-HSD2 during ex vivo human acute wound healing (n = 3) is shown. Induction of 11β-HSD2 48 h post wounding is shown. Quantitative real time PCR for the expression of 11β-HSD2 is shown. Expression levels were normalized to HPRT1. Error bars represent S.D. B, dexamethasone (Dex, 10−3 m) treatment for 6 h of human skin leads to a 4-fold induction of 11β-HSD2 (n = 3). Quantitative real time PCR for the expression of 11β-HSD2 is shown. Expression levels were normalized to HPRT1. Error bars represent S.D.