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. 2011 Jan 24;286(12):10367–10377. doi: 10.1074/jbc.M110.206532

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Increase of mitochondria mass in cardiomyocytes and decrease of survival time caused by MAP1S depletion suggest an impairment of autophagosomal degradation. A, increased mitochondrial mass in stressed MAP1S-deficient cardiomyocytes is shown. Data are the mean ± S.D. of three pairs of littermates. Significance was determined by Student's t test. B, reduced survival in starved MAP1S-deficient neonates is shown. The indicated significance of difference between survival curves for wild-type and knock-out mice was determined by Kaplan-Meier analysis.