FIGURE 9.

Rod outer segment structures in WT and P23H/+ mice. Transmission electron micrographs of ROS from WT (A and A′) and P23H/+ (B–F, B′ and C′) mice. Images were taken from PND 63 littermates. Disorganization of ROS was observed in all three analyzed P23H/+ mice (B, C, and D) as perpendicularly placed discs (arrows) or elongated discs (arrowheads). C, E, and F retinal images were obtained from one mouse to show disorganization at the incisure (C) and base of ROS (E) and both types of disorganization in a single OS (F). Lower magnification images of A–C are shown in A′–C′. Arrows correspond to perpendicularly placed discs. Arrowheads, perpendicularly placed elongated discs. Open arrowheads, vesicles. Open arrow in C, an incisure.