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A model showing the events in plasma membrane exposed to 2-val and 8-val TatP. HSPG exists as a monomer; 8-val TatP clusters with several HSPGs, leading to recruitment of Rac1 to lipid rafts, which triggers membrane reorganization of actin filaments and/or actin-dependent domains and induces the temporary immobilization and clustering of 8-val TatP/HSPGs. Rac1 activation induces TatP/HSPG internalization through macropinocytosis.
