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. 2011 Jan 18;286(12):10605–10617. doi: 10.1074/jbc.M110.211466

FIGURE 3.

FIGURE 3.

Acute exercise increases mRNA expression of nuclear and mitochondrial DNA-encoded mitochondrial transcripts without altering mtDNA copy number. A, shown are gene expression analyses of PGC-1α, Tfam, PDK4, nuclear DNA-encoded mitochondrial genes (CS, 5-aminolevulinate synthase (ALAS), cytochrome c, and COX-IV), and mtDNA-encoded mitochondrial genes (ND1, ND4, and COX-I) expression levels in skeletal muscle (quadriceps femoris) of END and END+3h groups compared with SED mice (n = 10/group) at three months of age. B, mtDNA copy number in skeletal muscle (quadriceps femoris) from SED, END, and END+3h mice (n = 10/group) is shown. mtDNA copy number is normalized to the diploid nuclear genome marker (β-globin). The asterisk (versus SED): *, p < 0.05; **, p < 0.01; †, p < 0.05 (versus both END and SED). Error bars represent S.E.