FIGURE 3.

Structure-activity relationships of branched, cyclic, and non-conjugated unsaturated SCAs at FFA2 and FFA3. A, DMR maximum (max) response (pm) concentration-response curves to branched/cyclic (panels i–vi) and non-conjugated unsaturated (panels vii–ix) SCAs (chemical structures are inset) were generated in cells stably expressing either FFA2 (circles) or FFA3 (squares). Data are mean ± S.E., n = 3. B, concentration-response curves of the same chemical series in IP₁ (FFA2) and cAMP (FFA3) assays. Data are mean ± S.E., n = 3.