Table 3.
Adjusted hazard ratios/odds ratios and 95% confidence interval for primary outcome by race (adjusted for age, gender, history of MI, heart failure, ancestry) and the p-value for SNP*treatment (calcium channel blocker treatment or beta blocker treatment strategy) interaction. The alleles shown in parentheses are the minor alleles.
| Caucasians | African Americans | Hispanics | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR/OR§ | p value | SNP*Treatment p value | HR/OR | p value | SNP*Treatment p value | HR/OR | p value | SNP*Treatment p value | |
| rs2357928 (G allele) | 0.72 (0.52-1.01) | 0.06 | 0.002* | 0.45 (0.20-1.0) | 0.049 | 0.32 | 0.58 (0.34-1.01) | 0.054 | 0.049 |
| rs11014166 (T allele) | 0.91 (0.57-1.45) | 0.68 | 0.4 | 1.03 (0.59-1.79) | 0.91 | 0.47 | 0.52 (0.24-1.13) | 0.097 | 0.16 |
| rs61839258 (T allele) | 1.13 (0.77-1.66) | 0.54 | 0.54 | 0.16 (0.03-1.04) | 0.055 | 0.98 | 1.36 (0.64-2.92) | 0.43 | 0.43 |
| rs7069292 (C allele) | 1.01 (0.74-1.38) | 0.97 | 0.24 | 0.75 (0.33-1.69) | 0.48 | 0.37 | 0.88 (0.51-1.52) | 0.65 | 0.46 |
HR: hazard ratios reported for rs23579278 and rs11014166 per each minor allele; OR: odds ratios reported for rs61839258 and rs7069292 for each minor allele.
The false discovery rate adjusted p value = 0.024.