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. 2011 Jan 4;589(Pt 5):1017–1030. doi: 10.1113/jphysiol.2010.201509

Figure 1. Receiver operating characteristic comparing the so-called gene count score based on 20 independently inherited diabetes risk alleles versus the Framingham Offspring score which considers several measures of blood lipids, age, sex, family history of diabetes, body mass index, blood pressure, and fasting glucose.

Figure 1

Note that the gene count score did only slightly better than the ‘no discrimination’ line and was much worse than the simple Framingham Offspring score. This figure shows the limited predictive power of common genetic variants that have been linked to disease risk. (Reproduced from Br Med J340, b4838 (Talmud et al. 2010) with permission from BMJ Publishing Group Ltd).