. 2011 Jan 4;589(Pt 5):1209–1220. doi: 10.1113/jphysiol.2010.203026

Table 4.

Haemodynamic and sympathetic responses to LBNP at rest and during handgrip in hypertensive subjects treated with an AT₁ receptor blocker

	Rest	Rest + LBNP	Handgrip	Handgrip + LBNP
No drug
MAP (mmHg)	106 ± 4	103 ± 4	112 ± 4^*	112 ± 5^*
HR (beats min⁻¹)	63 ± 2	65 ± 3	72 ± 1^*	74 ± 2^*
SNA (bursts min⁻¹)	34 ± 5	47 ± 2^*	41 ± 5	49 ± 3^*^†
Δ SNA (% total activity)	0 ± 0	62 ± 14^*	44 ± 15^*	109 ± 17 ^*^†
FBF (ml min⁻¹	113 ± 15	89 ± 10^*	627 ± 69^*	551 ± 63^*^†
FVC (units)	109 ± 16	88 ± 12^*	570 ± 73^*	498 ± 63^*^†
Irbesartan
MAP (mmHg)	97 ± 4^‡	97 ± 5^‡	102 ± 5^‡	104 ± 5^*^‡
HR (beats min⁻¹)	68 ± 3	72 ± 4^‡	74 ± 3^*	80 ± 4^*
SNA (bursts min⁻¹)	46 ± 4^‡^‖	58 ± 3^*^‡	53 ± 4^*^‡^‖	61 ± 5^*^‡^‖
Δ SNA (% total activity)	0 ± 0	46 ± 14^*	44 ± 21^*	102 ± 16^*^†
FBF (ml min⁻¹)	122 ± 14	97 ± 13^*	631 ± 105^*	631 ± 101^*
FVC (units)	129 ± 19	102 ± 16^*	626 ± 99^*	618 ± 98^*^‡
Washout
MAP (mmHg)	105 ± 3	102 ± 3	112 ± 4	112 ± 4
HR (beats min⁻¹)	65 ± 2	67 ± 3	70 ± 2^*	72 ± 4^*
SNA (bursts min⁻¹)	32 ± 4	49 ± 6^*	40 ± 5^*	46 ± 7^*
Δ SNA (% total activity)	0 ± 0	74 ± 25^*	46 ± 13^*	174 ± 44^*^†
FBF (ml min⁻¹)	166 ± 30	136 ± 16^*	560 ± 131^*	511 ± 124^*^†
FVC (units)	158 ± 35	123 ± 20^*	496 ± 111^*	452 ± 105^*^†

P < 0.05 vs. rest;

^†

P < 0.05 vs. handgrip

^‡

P < 0.05 vs. no drug,

^‖

P < 0.05 vs. washout; n= 7 subjects.