Table 2.
Transcripts with at least three fold higher levels in cells treated with SAHA alone vs. untreated cells
| (A) Transcripts changed by at least 3 fold after treatment with SAHA (alphabetical order): SKRC06 | |||
|---|---|---|---|
| Gene | Fold change SAHA/con | p value | Description |
| Akap2 | 3.127 | 0.0123 | A KINASE ANCHOR PROTEIN 2 |
| Atf5 | 0.31 | 0.00634 | ACTIVATING TRANSCRIPTION FACTOR 5 |
| Adcy7 | 0.312 | 0.00338 | ADENYLATE CYCLASE 7 |
| Akrc1c3 | 3.996 | 0.00391 | ALDO-KETO REDUCTASE FAMILY 1, MEMBER C3 |
| Ccl20 | 10.39 | 5.2e-5 | CHEMOKINE LIGAND 20 |
| Cyp1b1 | 0.328 | 0.00971 | CYTOCHROME-450, FAMILY 1, SUBFAMILY B, POLYPEPTIDE 1 |
| Ef1a | 4.144 | 0.000342 | EUKARYOTIC TRANSLATION ELONGATION FACTOR1, α 2 |
| Igsf4 | 3.076 | 0.00873 | IMMUNOGLOBULIN SUPERFAMILY, MEMBER 4 |
| Il1 α | 5.224 | 4.59e-6 | INTERLEUKIN1, α |
| Mbnl3 | 0.273 | 0.00851 | MUSCLEBLIND-LIKE 3 (DROSOPHILA) |
| Phf11 | 0.287 | 5.87e-5 | PHD FINGER PROTEIN 11 |
| Plekhc1 | 3.922 | 0.00162 | PLECKSTRIN HOMOLOGY DOMAIN CONTAINING, ,FAMILY C |
| Ryr1 | 0.191 | 0.0457 | RYANODINE RECEPTOR 1 |
| Serpinf1 | 0.294 | 0.000996 | SERPIN PEPTIDASE INHIBITOR, CLADE F |
| Slc1a1 | 3.518 | 0.00176 | SOLUTE CARRIER FAMILY 1 |
| Srpx | 7.497 | 9.12e-5 | SUSHI-REPEAT-CONTAINING PROTEIN, X-LINKED |
| Trim22 | 0.264 | 0.00504 | TRIPARTITE MOTIF CONTAINING 22 |
| At3 | 3.004 | 0.00259 | TUBULIN, α 3 |
| Znf518 | 0.33 | 0.028 | ZINC FINGER PROTEIN 518 |
| (B) Transcripts changed by at least 3 fold after treatment with SAHA: SKRC39 | |||
|---|---|---|---|
| Gene | Fold change SAHA/con | p value | Description |
| ube2l6 | 0.211 | 0.0411 | UBIQUITIN-CONJUGATING ENZYME E2L 6 |
| ugt | 0.278 | 0.0381 | UDP GLUCORONOSYL 1 FAMILY, POLYPEPTIDE A10 |
| kcns3 | 0.139 | 0.0374 | POTASSIUM VOLTAGE-GATED CHANNEL |
| ugt1a8 | 0.323 | 0.0282 | UDP GLUCORONYLTRANSFERASE 1, FAMILY |
| hpse | 0.333 | 0.0243 | HEPARANASE |
| rabac1 | 0.313 | 0.0217 | RAB ACCEPTOR 1 (PRENYLATED) |
| sc[e[1 | 0.170 | 0.0191 | SERINE CARBOXYPEPTIDASE |
| stom | 0.289 | 0.0119 | STOMATIN |
| eno2 | 0.174 | 0.0114 | ENOLASE 2 |
| fgf18 | 3.752 | 0.0112 | FIBROBLAST GROWTH FACTOR 18 |
| nef1 | 0.134 | 0.0112 | NEUROFILAMENT, LIGHT POLYPEPTIDE 68KDA |
| epas1 | 0.2 | 0.0112 | ENDOTHELIAL PAS DOMAIN PROTEIN 1 |
| gucy1b3 | 0.317 | 0.0112 | GUANYLATE CYCLASE, SOLUBLE, β 3 |
| nedd9 | 0.307 | 0.0112 | NEURAL PRECURSOR CELL EXPRESSED |
| gm2a | 0.291 | 0.0112 | GM2 GANGLIOSIDE ACTIVATOR |
| adrb2 | 0.191 | 0.00901 | ADRENERGIC, β 2, RECEPTOR, SURFACE |
| itpnc1 | 0.226 | 0.00901 | PHOPHATIDLINOSITOL TRANSFER PROTEIN, CYTOPLASMIC |
| akr1c3 | 0.32 | 0.00901 | ALDO-KETO REDUCTASE FAMILY 1, MEMBER C3 |
| at3 | 0.038 | 0.00721 | TUBULIN, α 3 |
| gsn | 0.148 | 0.00632 | GELSOLIN (AMYLOIDOSIS, FINNISH TYPE) |
| procr | 0.194 | 0.00439 | PROTEIN RECEPTOR, ENDOTHELIAL |
| c14orf78 | 0.299 | 0.00412 | CHROMOSOME 14 OPEN READING FRAME 78 |
| lmcd1 | 0.22 | 0.00412 | LIM AND CYSTEINE-RICH DOMAINS 1 |
| man1a1 | 0.264 | 0.00368 | MANNOSIDASE, α, CLASS 1A, MEMBER 1 |
| ccl20 | 0.123 | 0.000231 | CHEMOKINE (C-C MOTIF) LIGAND 20 |
(A) Genes with three sfold or greater changes in mRNA levels in SKRC06 are listed in alphabetical order. The fold-change, p value and gene description are shown. (B) Results for SKRC39; genes are listed by decreasing p value. The greatest fold change for a gene with increased mRNA levels after SAHA addition was fgf18.