Fig. 4.

Neonatal castration increases visits to the open arms of an EPM. The amount of time spent on (A) and number of entries into (B) the open arms of the EPM in Neo-Gdx or Neo-Sham Tfm and WT males. C, The number of total (open and closed) arm entries. Neo-Gdx rats had greater number of open arm visits than Neo-Sham rats (P < 0.01). They also tended to spend more time on the open arms (P = 0.063) and show a greater number of total arm entries (P = 0.062) than Neo-Sham males. These data indicate that neonatal castration decreases several indices of anxiety and may increase activity in adult rats in the EPM. Mean ± sem.