Figure 2. GAL4-p53 stimulates transcription-coupled polyadenylation.
(A) Purification of bacterially expressed GAL4-p53. His-tagged GAL4-p53 was purified by using talon resin and 5 μg resolved by SDS-PAGE.
(B) Transcription-polyadenylation assay with or without GAL4-p53. Transcripts produced in NE were analyzed on 5% denaturing gel and quantitated as in Fig. 1C.