Fig. 6.

Quantitation of feline cpg15 mRNA regulation in the LGN after monocular blockade. Data are presented for the left LGN, i.e., contralateral to the blocked eye. An index of activity regulation of feline cpg15 mRNA expression was obtained by dividing signal obtained in the eye-specific layer corresponding to the treated eye (A) by that obtained in the control layer (A1) (see Materials and Methods). Each column represents the mean ± SEM for three to five determinations from two to three independent animals.Asterisks indicate feline cpg15 ratios that are significantly different from controls shown on theleft (p < 0.01). The P38–P48 BDNF A/A1 ratio (numbersymbol) is significantly different from all other ratios (p < 0.001). The results indicate that feline cpg15 mRNA levels in the LGN are specifically regulated by visual experience after P20 and into adulthood. Analysis of data for the LGN ipsilateral to the injected eye (data not shown, but see Fig. 5) resulted in identical conclusions.