Fig. 4.

A simulation of photon scattering effect on image contrast in MMM tissue imaging. An original image comprising 5 × 5 microspheres of 10 μm diameter equally spaced with 40 μm separation distance and the experimentally measured PSF_tot was used in the simulation. (a) MMM image at the sample surface, (b) MMM image at imaging depth of $2.5\times l_{\text{s}}^{\text{em}}$, where increased background noise is observed in the center of the image. (c) The decay of SNR of the MMM image at its center location as a function of the imaging depth.