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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Expert Rev Clin Immunol. 2011 Jan;7(1):75–91. doi: 10.1586/eci.10.81

Table 1.

Damage-associated molecular pattern molecules that may be released after photodynamic therapy of tumors.

DAMP Name Function Responder cells Ref.
CRT Calreticulin ER-located calcium-binding protein [145]
HSP70, HSP90, gp96 Heat-shock proteins Inducible molecular chaperones on
cell surface
Monocytes, neutrophils [146]
HMGB1 High mobility group box-1 Nuclear chromatin-binding protein Monocytes, neutrophils [147]
ATP Adenosine triphosphate High-energy molecule, normally
intracellular
Dendritic cells, microglia [148]
S100S Calgranulin family members Calcium-binding proteins Monocytes, neutrophils [149]
SAP130 Spliceasome-associated
protein 130
Histone deacetylase complex subunit Macrophages [150]
dRP S19 Covalent dimer of ribosomal
protein S19
Constituent of small ribosomal subunit Monocytes, neutrophils [151]
Uric acid Mono sodium urate Derived from degradation of RNA
and DNA
Dendritic cells, neutrophils,
CD4+ and CD8+ T cells
[152]

DAMP: Damage-associated molecular patterns; ER: Endoplasmic reticulum; HSP: Heat-shock protein; PDT: Photodynamic therapy.