Table 1.
Damage-associated molecular pattern molecules that may be released after photodynamic therapy of tumors.
DAMP | Name | Function | Responder cells | Ref. |
---|---|---|---|---|
CRT | Calreticulin | ER-located calcium-binding protein | [145] | |
HSP70, HSP90, gp96 | Heat-shock proteins | Inducible molecular chaperones on cell surface |
Monocytes, neutrophils | [146] |
HMGB1 | High mobility group box-1 | Nuclear chromatin-binding protein | Monocytes, neutrophils | [147] |
ATP | Adenosine triphosphate | High-energy molecule, normally intracellular |
Dendritic cells, microglia | [148] |
S100S | Calgranulin family members | Calcium-binding proteins | Monocytes, neutrophils | [149] |
SAP130 | Spliceasome-associated protein 130 |
Histone deacetylase complex subunit | Macrophages | [150] |
dRP S19 | Covalent dimer of ribosomal protein S19 |
Constituent of small ribosomal subunit | Monocytes, neutrophils | [151] |
Uric acid | Mono sodium urate | Derived from degradation of RNA and DNA |
Dendritic cells, neutrophils, CD4+ and CD8+ T cells |
[152] |
DAMP: Damage-associated molecular patterns; ER: Endoplasmic reticulum; HSP: Heat-shock protein; PDT: Photodynamic therapy.