. Author manuscript; available in PMC: 2011 Mar 18.

Published in final edited form as: Biochem Soc Trans. 2010 Feb;38(Pt 1):132–136. doi: 10.1042/BST0380132

Table 1.

Ubiquitin ligases with published disease associations.

Pathology	Ubiquitin Ligases
Cancer	CARP2 (23), hdm2 (7, 24), SCF (^{β-TrCP/Skp2/Rbx4/SAG}) (11), BRCA1 (25),c-Cbl (26), CHIP (27), E6-AP (6), HACE1 (28), RNF5 (29), Pirh2 (30), pVHL (31)
Neurodegeneration	Parkin (32),TRIM11 (33), UCH-L1 (34), mahogunin (35), malin (36)
Metabolic diseases	Praja1 (37), MuRF1 (38), SCF^Atrogin1 (39),
Immune diseases	Hrd1 (40),TRAF6 (47), SLIM (42),GRAIL (43), ITCH (44),AIRE (45), ROQUIN (46)
Viral infection	Nedd4 (47), TRIM (48)