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. 2011 Mar;9(1):3–11. doi: 10.1089/lrb.2010.0016

FIG. 6.

FIG. 6.

Blockade of ROCK with Y-27632 caused lymphatic endothelial barrier dysfunction and also limited histamine-induced barrier dysfunction. (A) Application of the ROCK inhibitor Y-27632 decreased mean HMLEC-d TER, compared to vehicle alone (EBM). Also shown in (A) is the time course of TER changes after application of the vehicle control for histamine. (B) Application of histamine reduced mean TER in the vehicle group, but caused no further decrease in TER in the Y-27632 group. (C) The maximal decrease in TER caused by Y-27632 was significant compared to vehicle (evaluated within 30 min of application). (D) Histamine significantly decreased TER, but this was blocked by Y-27632 pretreatment. *P < 0.05 vs. control (Ctrl). §P < 0.05 vs. histamine (H). Other abbreviations: Y-27632 (Y), Y-27632 + Histamine (Y + H). N = 4 for all groups.