TABLE 2.

HIF-1 induced genes affected by HIF-1α siRNA (R), echinomycin (E, 100 nM), 1 (1 μM), and 3 (1 μM)

	HRE(s) (5′ to 3′)	R	E	1	3
TFRC	agcgTACGTGcctc	−2.0	−2.3	1.1	1.4
PKFB3	gcggGACGTGacgc gacgCACGTGggca	−5.5	−82.0	1.0	1.0
LDHA	ggcgGACGTGcggg ctcaCACGTGggtt	−1.7	−4.4	1.3	1.1
BNIP3	gccgCACGTGccac	−9.4	−6.0	1.3	1.0
EGLN3	gggcTACGTGcaga	−5.3	−33.6	1.0	−1.1
EGLN1	ggtgTACGTGcaga	−3.4	−19.8	1.1	1.0
PGK1	gtgaGACGTGcggc tgccGACGTGcgct	−5.4	−3.3	−1.2	1.0
CA9	gctgTACGTGcatt	−89.0	−9.4	−2.1	−1.1
VEGF	tgcaTACGTGggct	−3.4	−34.0	−2.0	−1.3
FLT1	gaacAACGTGgaat	−2.2	−4.7	−2.0	−1.1
EDN1	aggcAACGTGcagc	−3.5	−31.0	−2.5	1.3