Figure 1.

T cells are essential for liver regeneration. Mice underwent 70% partial hepatectomy (PH), and survival was monitored for 8 days. Data represent 1 of 2 independent experiments. N = number of mice per group. (A) Rag mice show an increased mortality after PH compared with WT. (B) Increased liver damage in Rag mice after PH. Serum aspartate aminotransferase (AST) levels at 48 hours after PH. (C) T cell-deficient mice (TCRβδ^–/–, designated TCR) show an increased mortality after PH. Mice with inactivation of TCRδ chain only (TCRδ^–/–) show normal survival. (D) T cell-deficient mice show reduced ratio of liver to body mass at 8 days after PH.