Figure 7.

Assigning each protein to the cell-cycle stage where its mRNA is expressed to its maximum level, we highlight each cluster according to the fractions of maximally expressed proteins in the underlying stage, where the color gradient from green to red refers to increasing fractions. We observe that nearly all highest activity of the clusters coincides with ring and schizont phases while, remarkably, almost no maximum-level activity is observed in the trophozoite phase. In the ring stage the strongest expressed clusters are involved in gene expression and protein production. In the late stage of the life cycle, the dominant protein interaction network highlights components of the proteasome, reflecting the requirement for total turnover as the parasite remodels itself for a shift to a new invasion stage.