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. 2011 Mar 18;6(3):e17703. doi: 10.1371/journal.pone.0017703

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Serra et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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As the threshold is increased the single breaks into smaller disjoint TESs, which correspond to more differentiated cells, until eventually final cell types are reached (i.e. single-TESs). Stochastic differentiation is explained by the fact that the new TES which is reached when the threshold is increased depends upon the attractor in which the cell is found and upon the node which is flipped (a few possible transitions are shown by dotted lines).

Inline graphic — As the threshold is increased the single breaks into smaller disjoint TESs, which correspond to more differentiated cells, until eventually final cell types are reached (i.e. single-TESs). Stochastic differentiation is explained by the fact that the new TES which is reached when the threshold is increased depends upon the attractor in which the cell is found and upon the node which is flipped (a few possible transitions are shown by dotted lines).