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. 2011 Mar 18;6(3):e17620. doi: 10.1371/journal.pone.0017620

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Stuckey et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Lack of the Hex-AVE leads to a failure to restrict Bmp2 expression to the proximal visceral endoderm and this leads to ectopic Wnt3 and Nodal expression in the anterior epiblast. This miss-localisation of Wnt3 and Nodal leads to the inability to correctly amplify Nodal in the posterior epiblast at 6.5dpc, causing defective specification of the anterior primitive streak.