Table 1. The top three discriminative genes for each grade (against the rest), through classification analysis based on both their expression levels (*P-value is obtained by Wilcoxon signed–rank test; “↓” denotes a down-regulated gene; REL means “raw expression level”).
| Subtype | REL-based signatures | |||
| Genes | AUC | *P-value | ClassificationAcc. (sen./spe.)% | |
| WD | MYO1B | 0.85 | 1.07E-03 | 81.5(75.0/82.6) |
| MET | 0.84 | 1.33E-03 | 80.9 (62.5/84.1) | |
| EDARADD↓ | 0.83 | 1.70E-03 | 72.3(85.7/69.7) | |
| MD | GKN2 | 0.77 | 1.42E-02 | 74.3(77.8/74.0) |
| SPP1 | 0.83 | 4.94E-04 | 75.7(66.7/76.3) | |
| PDIA2 | 0.87 | 7.82E-04 | 70.2(77.8/68.7) | |
| PD | CTSA | 0.76 | 1.21E-06 | 75.8 (87.5/62.0) |
| ADAMTS12 | 0.79 | 6.81E-08 | 75.0 (75.0/75.0) | |
| CST2 | 0.78 | 1.77E-07 | 74.2 (78.1/69.4) | |
| UD | COTL1 | 0.99 | 3.33E-01 | 96.4(100/96.4) |
| RHOJ↓ | 0.99 | 3.33E-01 | 97.1(100/97.1) | |
| TNFRSF1B | 0.99 | 3.33E-01 | 97.1(100/97.1) | |