Table 1. Eye abnormalities in αB-R120G knock-in mice.
Age (weeks) | 3–8 | 12–20 | 40–56 | Total (all ages combined) | |||
Genotype | Cataract (lens opacities) | ||||||
Cataract stage | Cataract stage | Cataract stage | |||||
WT | 2/10 (20%) | 0–0.5(0.3±0.3) | 1/4 (25%) | 0–0.5(0.6±0.6) | 4/7 (57%) | 1–1.5(1.2±0.3) | 7/21 (33%) |
Het | 17/17 (100%) | 1–3(1.4±0.6) | 6/10 (60%) | 0.5–3(1.7±1.0) | 10/10 (100%) | 2–4(2.6±0.8) | 31/37 (84%) |
Homo | 8/10 (80%) | 0–2(1.2±0.9) | 5/5 (100%) | 2–4(2.6±0.9) | 3/4 (75%) | 3–4(3.2±1.2) | 16/19 (84%) |
Small eye and lens | |||||||
WT | 0/10 (0%) | 0/4 (0%) | 0/7 (0%) | 0/21 (0%) | |||
Het | 5/17 (29%) | 0/10 (0%) | 3/10 (30%) | 8/37 (22%) | |||
Homo | 2/10 (20%) | 0/5 (0%) | 2/4 (50%) | 4/19 (21%) | |||
Corneal abnormalities | |||||||
WT | 0/10 (0%) | 0/4 (0%) | 0/7 (0%) | 0/21 (0%) | |||
Het | 2/17 (12%) | 0/10 (0%) | 0/10 (0%) | 2/37 (5%) | |||
Homo | 1/10 (10%) | 0/5 (0%) | 2/4 (50%) | 3/19 (16%) |
WT, wild-type; Het, heterozygous; Homo, homozygous.