Figure 5.

Relationship of Th17 cells to cytomegalovirus (CMV) immune recovery uveitis (IRU) disease, CMV-specific T cells, and regulatory T (T_reg) cells . A, The number of Th17 cells detected in patients and control subjects at the index visit. Symbols and statistics are as described for Figure 1. B, Dotplot showing the Th17:T_reg ratio in patients and control subjects at the index visit. The ratio was calculated by dividing the fraction of Th17 cells among CD4⁺ T cells by the fraction of T_reg cells (CD3⁺CD4⁺CD25⁺CD127^low) among CD4⁺ T cells. C, Relationship between Th17 cells, shown on the X axis, and CMV-specific responses among CD8⁺ T cells, shown on the Y axis. The measure shown is a sum of the fraction of cells found to produce IL-2 alone, TNF-α alone, both cytokines combined, or both cytokines in combination with IFN-γ. D, Relationship between Th17 cells and T_reg cells at the index visit. E, Relationship between Th17 cells and T_reg cells at the pre-index visit.