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. 2011 Mar 18;6(3):e18012. doi: 10.1371/journal.pone.0018012

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Walenda et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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174 human serum proteins were analyzed in serum samples of six patients (#1–6) obtained before chemotherapy (BC) or at day 8 after HSCT. Detection of platelet-derived growth factor (PDGF)-AA, -AB, -BB, matrix metallopeptidase -9 (MMP-9), leukocyte alkaline phosphatase (LAP), L-Selectin, leukemia inhibitory factor (LIF) and chemokine [C-X-C motif] ligand 10 (IP-10) was higher before chemotherapy, whereas only chemokine [C-C motif] ligand 2 (MCP-1) significantly increased after chemotherapy. Additional comparison of chemokine profiles in serum samples at further time points (BC and from d4, d8, d11, d14 and d18 after HSCT) revealed that these changes in growth-factor concentration are transient during aplasia and normalize after hematopoietic recovery.