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. 2011 Mar 18;6(3):e18020. doi: 10.1371/journal.pone.0018020

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Meis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Examples of glutamatergic sEPSCs recorded in a LA projection neuron before and (B) during action of NPS. (C) Cumulative amplitude and (D) inter-event interval histograms obtained from the same neuron shown in (A, B) before addition of NPS and after a steady-state effect had been reached. (E) Normalized sEPSC amplitude and frequency pooled during control conditions and after addition of NPS demonstrates a significant increase in sEPSC amplitude as well as frequency. (F) Time course of NPS effect and input resistance for a representative PN. (G, H) Under current-clamp conditions, NPS application induces a depolarizing response associated with increased spike activity triggered upon depolarizing current injections in LA projection neurons. * P<0.05, ** P<0.01.