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. 2011 Mar 18;6(3):e18020. doi: 10.1371/journal.pone.0018020

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Meis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Cumulative amplitude and (B) inter-event interval histograms obtained before and after NPS addition from a neuron showing no effect mediated by NPS. (C) In 9 out of 20 neurons, mEPSCs recorded in the presence of TTX were unchanged in amplitude as well as frequency by addition of NPS, as verified by the Kolmogorov-Smirnov test. (D) Cumulative amplitude and (E) inter-event interval histograms obtained from a neuron showing an increase in frequency after addition of NPS. (F) Normalized mEPSC amplitude and frequency pooled during control conditions and after addition of NPS demonstrates a significant increase in sEPSC frequency in a subpopulation of 11 out of 20 projection neurons. ** P<0.01.