Table 3.
Descriptive characteristics of supporting sample: 362 ADNI subjects with CSF only.
| Characteristic | All (n = 362) |
CN (n = 105) |
aMCI (n = 164) |
AD (n = 93) |
|---|---|---|---|---|
| Female gender, no. (%) | 148 (41) | 51 (49) | 57 (35) | 40 (43) |
| Age, years, median (IQR) | 76 (71, 80) | 76 (72, 78) | 75 (70, 80) | 77 (71, 81) |
| APOE ε4 positive, no. (%) | 174 (48) | 23 (22) | 86 (52) | 65 (70) |
| Education, years, median (IQR) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | 16 (13, 18) |
| MMSE, median (IQR) | 27 (25, 29) | 29 (29, 30) | 27 (25, 28) | 24 (22, 25) |
| CDR-SB, median (IQR) | 1.5 (0.0, 3.0) | 0.0 (0.0, 0.0) | 1.5 (1.0, 2.0) | 4.0 (3.5, 5.0) |
| PIBcalc, median (IQR) | 1.9 (1.5, 2.3) | 1.5 (1.4, 1.9) | 2.0 (1.6, 2.3) | 2.2 (1.9, 2.4) |
| PIB Positive (>1.5 by PIBcalc), no. (%) | 266 (73) | 47 (45) | 132 (80) | 87 (94) |
Abbreviations: IQR, inter-quartile range; APOE, apolipoprotein E; MMSE, Mini-Mental State Examination; CDR-SB, Clinical Dementia Rating sum of boxes; PIB, Pittsburgh Compound B; PET, positron emission tomography; PIBcalc, calulated PIB PET based on CSF Aβ42.