Table 2.
Characteristics of patients with NAFLD according to Early (Stages 0-2) versus Advanced (Stages 3-4) liver fibrosis*
| Stages 0-2 (n=742) | Stages 3-4 (n=338) | p-value | |
|---|---|---|---|
| Female Gender | 445 (60.0%) | 238 (70.4%) | 0.001 |
| Age (years) | 46.7 ± 11.9 | 54.0 ± 10.4 | <0.0001 |
| Race / Ethnicity | 0.007 | ||
| White | 556 (75.1 %) | 273 (80.8%) | |
| Hispanic | 99 (13.4%) | 22 (6.5%) | |
| Black | 20 (2.7%) | 8 (2.4%) | |
| Other | 65 (8.8%) | 35 (10.4%) | |
| Hispanic, yes vs. no | 99 (13.3%) | 22 (6.5%) | 0.0008 |
| BMI, kg/m2 | 34.0 ± 6.3 | 34.9 ± 6.5 | 0.03 |
| BMI >=30 kg/ m2 | 515 (69.9%) | 253 (74.9%) | 0.10 |
| Diabetes Mellitus Type 2 | 164 (22.1%) | 154 (45.6%) | <0.0001 |
| History of Regular Smoking, yes vs. no | 194 (26.3%) | 114 (33.8%) | 0.01 |
| Current smoker, yes vs. no | 67 (9.1%) | 34 (10.1%) | 0.65 |
| History of >=10 vs. <10 pack-years | 147 (20.0%) | 109 (32.3%) | <0.0001 |
| Pack-years, median (IQR) | 0 (0.0, 6.0) | 0 (0.0, 16.5) | 0.0002 |
| Alcohol use, not abstinent vs. lifetime abstinent | 389 (52.4%) | 147 (43.5%) | 0.007 |
| Household income <15,000 vs. >=15,000/year | 62 (8.5%) | 30 (9.0%) | 0.81 |
| Biopsy length, mm | 18.2± 9.5 | 19.9 ± 10.6 | 0.01 |
*
Expressed as percent for categorical variables and mean (±SD) for continuous variables. Median (IQR) is shown for pack-years variable because of its non-normal distribution.