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Comparison of the regulation of PP1 and PP1/PP2A chimeras by thiophospho-DARPP-32. Phosphatase activity was measured in the presence of the indicated concentrations of thiophospho-DARPP-32. (A) Inhibition of wild-type PP1 and C-terminal domain mutants derived from PP1 as indicated. (B) Inhibition of PP1/PP2A chimera and mutants derived from the chimera as indicated. Phosphatase activity was measured as described in the Fig. 1 legend.
