Skip to main content
. 2011 Feb 1;30(6):994–1002. doi: 10.1038/emboj.2011.19

Figure 4.

Figure 4

Mutations at position 660 affect the voltage dependence of proton activation. (A) Representative whole-cell current traces for TRPV1 (F660S) and TRPV1 (F660Y) mutants elicited by a voltage step protocol in response to protons as indicated. (B, C) Normalized steady-state maximal conductance curves at different pH values obtained from current traces shown in A. Lines represent Boltzmann fit to the data. (D) ΔV1/2 as a function of pH for wild type, F660S, and F660Y (n=5–6, *P<0.05, **P<0.01). Lines represent Hill fit to the data. Error bars represent s.e.m. (E) Comparison of ΔV1/2 for wild type, F660S, and F660Y in response to 1 μM capsaicin (n=4–5, P>0.05). Error bars represent s.e.m.