Figure 3.

Fidelity of individual base pair substitutions for human Pol ε and human Pol δ. Error rates for each of the 12 possible mispairs for the exonuclease-deficient forms of human Pol ε (black bars, this study) and human Pol δ [white bars, (58)] were calculated as described (54). P-values are shown above each comparison to a human Pol ε error rate where the difference was found to be significant. The (asterisk and double asterisk) symbols indicate P-values where P ≤ 0.05 and 0.005, respectively.