Figure 3.

Role of activin and TGF-β receptors in fibre differentiation. Null mutations of Acvr2b (a–d) or Tgfbr2 (e, f) do not affect lens development. However, expression of a dominant-negative Tgfbr2 receptor results in the failure of terminal lens fibre differentiation (h). (a–d); Tissues courtesy of Dr S. Paul Oh, de Iongh, 2004, unpublished data, University of Florida, Gainesville, FL, USA. (e,f) Reproduced and adapted with permission from Beebe et al. [55]. (g,h) Adapted from de Iongh et al. [37].