Table 2.
Top 10 over-represented pathway interactions enriched for interactions between mutated genes in cancer in mixPCN (ranked by decreasing counts of mutated gene pairs).
| pathway A | pathway B | mutationa(allb) |
|---|---|---|
| IFN-γ pathway | class I PI3K signalling events | 238(555) |
| class I PI3K signalling events mediated by Akt | TGF-β receptor signalling | 225(624) |
| class I PI3K signalling events mediated by Akt | regulation of cytoplasmic and nuclear SMAD2/3 signalling | 225(624) |
| ErbB receptor signalling network | IL-1-mediated signalling events | 212(445) |
| proteogylcan syndecan-mediated signalling events | TRAIL signalling pathway | 202(557) |
| class I PI3K signalling events | coregulation of androgen receptor activity | 196(414) |
| proteogylcan syndecan-mediated signalling events | IFN-γ pathway | 187(573) |
| class I PI3K signalling events mediated by Akt | androgen-mediated signalling | 183(470) |
| BMP receptor signalling | integrins in angiogenesis | 177(354) |
| androgen-mediated signalling | IL-1-mediated signalling events | 173(442) |
aNumber of interactions between mutated genes in cancer existing between pathways A and B.
bNumber of all gene interactions existing between pathways A and B.