Table 3.
Top 10 over-represented pathway interactions enriched for interactions between mutated genes in cancer in mixPCN (ranked by increasing p-values of mutated gene pairs).
| pathway A | pathway B | mutationa(allb) |
|---|---|---|
| class I PI3K signalling events mediated by Akt | syndecan-1-mediated signalling events | 143(407) |
| sphingosine 1-phosphate (S1P) pathway | p75(NTR)-mediated signalling | 136(291) |
| sphingosine 1-phosphate (S1P) pathway | LPA receptor mediated events | 136(262) |
| p53 pathway | regulation of androgen receptor activity | 125(251) |
| ErbB receptor signalling network | BCR signalling pathway | 106(177) |
| angiotensin II mediated activation of JNK pathway via pyk2 dependent signalling | signalling events mediated by Stem cell factor receptor (c-Kit) | 103(153) |
| glypican pathway | IFN-γ signalling pathway | 103(153) |
| integrins in angiogenesis | keratinocyte differentiation | 97(166) |
| ephrinA-EPHA pathway | BCR signalling pathway | 89(139) |
| signalling events mediated by stem cell factor receptor (c-Kit) | growth hormone signalling pathway | 84(118) |
aNumber of interactions between mutated genes in cancer existing between pathways A and B.
bNumber of all gene interactions existing between pathways A and B.