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Mammalian Superoxide Dismutase
| CuZnSOD (SOD1) | MnSOD (SOD2) | Extracellular SOD (SOD3) | |
|---|---|---|---|
| Location | Cytosol | Mitochondria | Extracellular space |
| MW (Da) | 32,000 | 88,000 | 120,000 |
| Metal factor | Cu (catalytic active) | Mn (catalytic active) | Cu (catalytic active) |
| Zn (enzyme stability) | Zn (enzyme stability) | ||
| Chromosome | 21 (human) | 6 (human) | 4 (human) |
| 16 (mouse) | 17 (mouse) | 5 (mouse) | |
| Disease | Amyotrophic lateral sclerosis (familial) | Familial amyloidotic polyneuropathy, type I | ? |
SOD, superoxide dismutase.
