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. Author manuscript; available in PMC: 2011 Mar 20.
Published in final edited form as: Int J Biochem Cell Biol. 2007 Oct 24;40(12):2675–2680. doi: 10.1016/j.biocel.2007.10.023

Figure 1. eIF4E sequence and structure.

Figure 1

Primary sequence of human (P06730), mouse (NM00917) and Saccharomyces cerevisiae (M15436) eIF4E, highlighting the high degree of sequence conservation. Three dimensional structure of mouse eIF4E in a complex with m7GDP and a peptide from eIF4G (PDB 1EJ4). Residues important for cap binding (W56 and W102) and ligand binding (W73) are highlighted