Skip to main content
. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Immunol. 2010 Apr 28;184(11):5954–5958. doi: 10.4049/jimmunol.1000265

FIGURE 1.

FIGURE 1

DCs induce tolerance of tumor-infiltrating effector T cells in the prostate tumor tissue. A, CD11c+ cells were isolated from the spleens and prostates of B6, TRAMP, and TRP-SIY mice by cell sorting and were then stained for PDCA-1, Gr-1, or B220. Dot plots shown are from five pooled mice in each group and are representative of two similar experiments. Experimental protocol (B) and effect of DC depletion on 2C T cell function (C). Cells from the spleens and prostates of BMT mice were stained for 2C TCR, Thy1.1, and intracellular IFN-γ. Density plots show Thy1.1 versus IFN-γ profiles of 2C TCR+ Thy1.1+ cells. Numbers indicate the average percentage of positive cells ± 1 SD. Data are representative of two to three mice per group. *p < 0.05 when compared with control.