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. Author manuscript; available in PMC: 2012 Mar 11.
Published in final edited form as: J Mol Biol. 2010 Dec 9;406(5):713–729. doi: 10.1016/j.jmb.2010.12.005

Figure 5.

Figure 5

The two signature pockets of the MMP-3 sub-group accommodate different configurations of the side chains of the bound inhibitors. The signature pocket for MMP-3A (Fig 4A) mapped on to a representative structure A) with the inhibitor shown (PDB 1hfs), and B) with inhibitor removed for visualization (PDB 1c8t). C). Four inhibitors taken from structures of the MMP-3 A cluster. All MMP-3 A bound inhibitors have extended side chains (shown in square). The MMP-3 B signature pocket 4B mapped onto a representative structure (PDB 1g05) D) with the inhibitor shown, and E) with inhibitor removed for visualization (1d8f). F). Four inhibitors taken from representative structures of the MMP-3B cluster. All MMP-3 B bound inhibitors have short side chains.