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Classification of NAD binding proteins and their signature bind pockets. A.) The hierarchical tree resulting from clustering of NAD-binding pockets. B–J.) The signature pockets of the NAD binding proteins, along with the NAD cofactors bound in the member structures of the respective clusters superimposed. The NAD cofactor has two distinct conformations. Those in an extended conformation are marked with an “X”, and those in a compact conformation are marked with a “C”.
