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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2010 Jul 10;67(5):995–1006. doi: 10.1007/s00280-010-1395-9

Table 4.

Pharmacokinetic parameters for SR13668a

iv, 1 mg/kg (6 mg/m2)
po, 1 mg/kg (6 mg/m2)
po, 10 mg/kg (60 mg/m2)
po, 30 mg/kg (180 mg/m2)
Male Female Male Female Maleb Female Male Female
t1/2 (h) 4.4 ± 0.4 5.6 ± 2.2 7.5 ± 1.3 7.1 ± 0.6 5.6 9.0 ± 4.4 9.6 ± 1.3 7.3 ± 1.1
Tmax (h) NA NA 4.0 ± 4.4 3.3 ± 1.2 5.7 ± 3.4 5.3 ± 1.2 6.3 ± 2.5 8.0 ± 1.7
C0 (ng/ml) 1,435.7 ± 233.2 1,557.8 ± 299.4 NA NA NA NA NA NA
Cp (ng/ml) 925.8 ± 82.4 933.0 ± 113.4 17.1 ± 10.9 23.2 ± 18.4 130.1 ± 63.6c 531.5 ± 216.8c 455.5 ± 85.5c 883.9 ± 82.4c
AUClast (ng h/ml) 1,124.7 ± 99.2c 1,601.0 ± 157.1c 130.3 ± 26.2 236.6 ± 118.0 1,446.6 ± 277.6c 6,560.6 ± 2,133.3c 7,038.1 ± 1,347.3c 12,365.0 ± 1,957.0c
AUCinf (ng h/ml) 1,138.7 ± 100.5c 1,668.8 ± 114.8 143.7 ± 22.6 262.37 ± 127.1 1,699.2 8,236 ± 2,797.3c 8,676.9 ± 1,300.1c 13,857.9 ± 1,961.5c
V or V/F (L/kg) 5.6 ± 0.8 4.8 ± 2.0 77.7 ± 26.1 49.7 ± 32.4 49.4c 16.9 ± 5.2c 49.3 ± 12.4c 23.2 ± 6.3c
Cl or Cl/F
(ml/h/kg)
883 ± 82c 601 ± 41c 7,085.3 ± 1,196.9 4,767.0 ± 3,002.3 5924c 1,340.3 ± 559.7c 3,507.0 ± 495.3c 2,193.0 ± 295.3c
MRT (h) 3.6 ± 0.3 5.8 ± 2.0 10.4 ± 2.2 10.6 ± 1.2 9.1 14.8 ± 7.0 14.9 ± 1.5 11.8 ± 0.8
F (%) 12.6 ± 2.0 15.7 ± 7.6 14.9 49.4 ± 16.8 25.4 ± 3.8 27.7 ± 3.9

Values represent the mean ± SD of n = 3 unless noted otherwise

a

Parameters requiring calculation of the terminal phase are for n = 2 rats, other parameters calculated with n = 3

b

Values of males and females signiWcantly diVerent, P < 0.05