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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2010 Dec 16;22(6):698–705. doi: 10.1111/j.1540-8167.2010.01972.x

Figure 2.

Figure 2

Effects of losartan on isoproterenol-induced DADs and triggered activity in a PV sleeve preparation. (A) Each panel depicts a train of 10 beats at a basic cycle length (BCL) of 500, 300 and 150 ms followed by a pause. Isoproterenol (Iso, 1 µM) induces prominent rate-dependent DADs and triggered activity during the pause. Addition of losartan (1 µM) suppresses the triggered beats and a small DAD persists at BCL 150ms Washout of losartan restores DADs and triggered beats. (B) Effects of losartan on acetylcholine (ACh)/high calcium-induced late-phase 3 EADs in a PV sleeve preparation. Each panel shows the first 3 beats following a train of 20 beats at basic cycle length (BCL) of 300 and 200 ms. (ACh (1µM) and high calcium (5.4mM) induce rate-dependent late-phase 3 EADs. Losartan (1uM) eliminates EAD activity. Washout of losartan restores EADs.