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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2010 Dec 3;17(5):620–631. doi: 10.1016/j.bbmt.2010.11.029

Figure 3. Intensified PC and FC regimens result in profound immune depletion.

Figure 3

(a) Host B6 mice were treated with a 14-day course of either pentostatin (P; 1mg/kg on days 1, 4, 8 and 12) or fludarabine (F; 100mg/kg on days 1, 4, 8. and 12) alone; daily cyclophosphamide alone (C100; 100 mg/kg/day); a combination of intermittent pentostatin or fludarabine with daily cyclophosphamide (P/C100 or F/C100); or treated with lethal total body irradiation (1150 cGy). Spleen cells were isolated and evaluated by flow cytometry for total number of CD4+ and CD8+ T cells and myeloid cells (Gr-1+). (b) Bone marrow cells were also analyzed for T cell composition and myeloid lineage. All results are shown as mean ± SEM of n=5 per cohort.