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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Am J Obstet Gynecol. 2011 Jan 26;204(3):254.e16–254.e28. doi: 10.1016/j.ajog.2010.11.032

Figure 4. mRNA Expression of Brain Injury Indices is Increased by Chronic Fetal Hypoxia.

Figure 4

Cerebral cortex, hippocampus and thalamus nuclei were selectively biopsied at the sites of injury discovered in the brain slices using laser capture microdissection (LCM) and ATF3, GFAP and Bax mRNA expressions measured by Q-rtPCR. The mRNA expression for each injury marker was up regulated by chronic hypoxia (n=6, p<0.05) in both whole brain samples and at each of the LCM biopsied sites. These results, combined with the immunostaining findings demonstrate that chronic hypoxia selectively injures the fetal brain and that both mRNA and protein levels are increased.