Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Apr 30;136(1):1–12. doi: 10.1016/j.imlet.2010.10.005

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 Elsevier B.V.

Open Access under CC BY 3.0 license

PMC Copyright notice

Fig. 1 — C-type lectin receptors encoded by the natural killer gene complex (NKC). The murine NKC comprises genes located on chromosome 6F3 and spans a region of approximately 2.5 Mb. In humans, its equivalent is located on chromosome 12p13.1. The dectin-1 cluster (black dashed square) comprises genes encoding group V CLRs including MICL (G), CLEC-2, CLEC-9A, MAH (H), CLEC-1, dectin-1 (B) and LOX-1. The dectin-2 cluster (black dotted square) comprises genes centromeric to the NKC which encode group II CLRs including BDCA-2, DCAR (A), DCIR (D), dectin-2, CLECSF8 and Mincle. The murine Ly49 family (black solid square) includes both activating receptors such as Ly49H (C) and inhibitory receptors such as Ly49Q (I). Genes encoding MAFA/KLRG1 (humans) and its murine orthologue (klrg1) are highlighted in solid grey squares. Names in italics represent genes present in humans but absent from the mouse NKC. Upper panels show activating receptors and bottom panels show inhibitory receptors, both in order of chromosomal localisation from left (centromeric) to right (telomeric). ITAM: ; ITIM: ●; ITAM-like: ○. Activating receptor substrates such as Src and Syk kinases and inhibitory receptor substrates such as protein tyrosine phosphatases SHP-1,-2 and SHIP are also shown. (E) Rat MAFA inhibits the secretory response induced by IgE-mediated FcɛRI aggregation, (G) human MICL ligation suppresses TLR-induced responses within specific immune and cellular contexts.

Inline graphic — C-type lectin receptors encoded by the natural killer gene complex (NKC). The murine NKC comprises genes located on chromosome 6F3 and spans a region of approximately 2.5 Mb. In humans, its equivalent is located on chromosome 12p13.1. The dectin-1 cluster (black dashed square) comprises genes encoding group V CLRs including MICL (G), CLEC-2, CLEC-9A, MAH (H), CLEC-1, dectin-1 (B) and LOX-1. The dectin-2 cluster (black dotted square) comprises genes centromeric to the NKC which encode group II CLRs including BDCA-2, DCAR (A), DCIR (D), dectin-2, CLECSF8 and Mincle. The murine Ly49 family (black solid square) includes both activating receptors such as Ly49H (C) and inhibitory receptors such as Ly49Q (I). Genes encoding MAFA/KLRG1 (humans) and its murine orthologue (klrg1) are highlighted in solid grey squares. Names in italics represent genes present in humans but absent from the mouse NKC. Upper panels show activating receptors and bottom panels show inhibitory receptors, both in order of chromosomal localisation from left (centromeric) to right (telomeric). ITAM: ; ITIM: ●; ITAM-like: ○. Activating receptor substrates such as Src and Syk kinases and inhibitory receptor substrates such as protein tyrosine phosphatases SHP-1,-2 and SHIP are also shown. (E) Rat MAFA inhibits the secretory response induced by IgE-mediated FcɛRI aggregation, (G) human MICL ligation suppresses TLR-induced responses within specific immune and cellular contexts.